You should read this about the progressive nature of the seizures from nerve agents, where it becomes self-compounding.
"This paper proposes a three phase "model" of the neuropharmacological processes responsible for the seizures and neuropathology produced by nerve agent intoxication. Initiation and early expression of the seizures are cholinergic phenomenon; anticholinergics readily terminate seizures at this stage and no neuropathology is evident. However, if not checked, a transition phase occurs during which the neuronal excitation of the seizure per se perturbs other neurotransmitter systems: excitatory amino acid (EAA) levels increase reinforcing the seizure activity; control with anticholinergics becomes less effective; mild neuropathology is occasionally observed. With prolonged epileptiform activity the seizure enters a predominantly non-cholinergic phase: it becomes refractory to some anticholinergics; benzodiazepines and N-methyl-D-aspartate (NMDA) antagonists remain effective as anticonvulsants, but require anticholinergic co-administration; mild neuropathology is evident in multiple brain regions. Excessive influx of calcium due to repeated seizure-induced depolarization and prolonged stimulation of NMDA receptors is proposed as the ultimate cause of neuropathology. The model and data indicate that rapid and aggressive management of seizures is essential to prevent neuropathology from nerve agent exposure."
In JFK, we see his condition worsening. Top left is 225, where nothing stands out as unusual. Then in 232, he's doing the bizarre winging of his arms, which is not the normal way to raise your hands. Then, in 253, his arms are stuck; they're frozen; he can't put them down. Jackie is trying to coax his arms down, and in 263, you can see that she has tilted him, but, his spasms have not let up. And you can see that he is getting tighter in his neck and shoulders. Then in 312, the last frame before the fatal head shot finished him, he is tighter yet and even more contracted. He is also completely internalized.
And if he wasn't hit again after 312, the spasms may have spread to his respiratory muscles, preventing him from breathing and causing death by suffocation. It was certainly possible considering how it was progressing.
JFK's psycho and neuro pathology has been staring us in the face. I don't know how people ignored it. All I can surmise is that they had the mindset that it was JFK-land, and weird stuff happened in JFK-land, like it was its own unique world.

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